Senior Manager, Oncology Trial Navigation

Senior Manager, Oncology Trial Navigation

About the Role

The Senior Manager of Oncology Trial Navigation will drive operational scalability and execution of our oncology trial navigation program, playing a critical role in supporting the connection of Signatera patients to appropriate clinical trial opportunities while focusing on strategic program growth and team leadership.

You will serve as the operational bridge between Natera’s centralized patient screening team and external stakeholders—including treating oncologists, principal investigators (PIs), research coordinators, and, when appropriate, patients themselves.

You will play a key role in operationalizing and scaling the oncology focused trial navigation program, partnering with internal stakeholders to harmonize best practices, refine clinical workflows, and scale the team’s reach. This is a unique opportunity for an experienced clinician to drive strategic development of a function that directly accelerates oncology clinical trial enrollment in a fast-scaling, mission driven environment. This role demands exceptional communication and cross functional collaboration to successfully deliver and expand clinical trial support in the oncology domain.

What You’ll Do

Physician & Site Engagement

• Deliver patient eligibility notifications and facilitate referral workflows.

●      Support site prioritization and activation strategies.

●      Ensure timely follow-up and outcome tracking.

Trial Matching Coordination

●      Operationalize outputs from Natera’s AI-enabled trial matching platform.

●      Support eligibility review by aligning molecular and clinical data with trial inclusion/exclusion criteria.

●      Track patient progression from identification through referral and enrollment.

Patient & Caregiver Support (as applicable)

●      Provide high-level, compliant education about trial opportunities.

●      Coordinate seamless handoffs to site research teams.

●      Approach all patient interactions with empathy and professionalism.

Operational Excellence

●      Support business development by providing clinical feasibility insights.

●      Maintain accurate documentation of outreach and referral activities.

●      Use tracking tools to monitor performance metrics.

●      Develop SOPs and continuous process improvement to support and scale operational excellence in Oncology Trial Navigation that are harmonized with existing Natera departments.

●      Participate in cross-functional collaboration with Clinical Ops, Medical, Data Science, and Business Development.

●      Proactively identify opportunities for process optimization, communication strategies, and contribute to organizational growth through development and implementation of operational strategy and best practices.

Leadership and Team Building

●      Lead the hiring, onboarding, and professional development of Oncology Trial Navigation IC roles to scale this function.

●      Provide direct coaching on clinical navigation, complex stakeholder management, and empathy-led patient trial matching outreach.

●      Define performance metrics and drive a culture of continuous improvement, ensuring the team is equipped to meet growing trial demand.

Qualifications

Education & Licensure:

●      Current, active licensure as a Registered Nurse, Certified Genetic Counselor, Nurse Practitioner, Physician Assistant or other advanced clinical licensure.

○      Required to maintain licensure in good standing throughout employment.

○      Board Certification (e.g. OCN, CCRC or similar) is highly preferred.

●      A master's degree in a clinical or scientific field is highly preferred.

Professional Experience:

●      5+ years of oncology clinical experience, with at least 3 years specifically in oncology clinical research.

●      Preference for experience specifically in patient identification and trial matching services at a leading molecular diagnostics laboratory or independent clinical trial matching company.

Leadership Experience:

●      Proven experience in building and scaling a clinical program.

●      Demonstrated ability to manage direct reports and mentor team members in a fast paced environment.

●      Strong initiative and follow through discipline.

Clinical Expertise:

●      Advanced clinical knowledge in oncology with deep understanding of biomarker driven oncology, MRD based clinical trial landscapes

●      Expert-level understanding of clinical trial design and the ability to interpret complex inclusion/exclusion criteria.

●      Familiarity with centralized screening or trial referral models.

●      Experience communicating with patients, physicians, PIs, and research coordinators.

Technical & Data Proficiency:

●      Ability to quickly learn new technologies and serve as primary business stakeholder for technological solutions utilized in Oncology Trial Navigation.

●      Proactive in identifying inefficiencies and partnering with technology teams to facilitate solution development.

●      Comfortable navigating large datasets and  translating complex clinical trial protocols into structured data requirements.

Core Competencies

●      Ability to design, implement, and scale clinical navigation workflows.

●      Proven success as both an individual contributor and effective people leader.

●      Exceptional communication and interpersonal skills.

●      High degree of empathy and professionalism in patient-facing interactions.

●      Strong organizational skills and follow through discipline.